Lowes was born in Queens, New York City and grew up in Port Washington, New York, where she graduated in 2000 from Paul D. Schreiber Senior High School. Her father is Irish Catholic, and her mother is Jewish.
She gradua… See more

She was cast in the stage play Four Saints in Mexico. In 2004, Lowes landed her first screen role in the FX series Rescue Me and later co-starred opposite Marcia Gay Harden in the Showtime pilot, Hate. Lowes later guest … See more

Lowes lives in Los Angeles with her husband, actor Adam Shapiro. Shapiro played her character's boyfriend in an episode of Scandal. In May 2017, she announced that she and her husband were expecting t… See more